Thursday, Dec 20, 2018, 8:00 AM - Friday, Dec 21, 2018, 5:00 PM EST
Donna Shalala Student Center
University of Miami
1330 Miller Drive
Miami FL 33146
Dear Colleagues,
On behalf of the organizing committee, it is our great pleasure to invite you to participate in the International Symposium on Pathomechanisms of Amyloid Diseases from December 20-21, 2018 in Miami, FL, United States.
The purpose of this two day meeting is to bring established investigators and junior researchers together to expand this exciting field. Attendance will be limited, making it an ideal setting for discussion and learning.
The scientific program will consist of lectures from the top international experts in the field as well as in-depth discussions during the informal sessions. Our aim is to summarize what is scientifically known, learn about the cutting-edge research and to create a forum where junior trainees can meet and network with established investigators.
The topics include
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Pathology of amyloid aggregation
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Structural, dynamics and kinetics of folding and misfolding of amyloid proteins
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Amyloid inhibitors
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In-vivo studies on amyloids
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New approaches to study amyloid proteins
Key reasons to participate
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Discover the late-breaking and cutting edge science which will be presented during the scientific sessions
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Participate in scientific discussions
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Attend state-of-the-art lectures by world experts in the fields
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Network with other colleagues in the field
Thank you and we look forward to meeting you in Miami in December.
With best wishes and warm regards,
Varan Govind (University of Miami)
Ayyalusamy (Rams) Ramamoorthy (University of Michigan)
Downloads:
All Speakers and students/postdocs who wish to present their work are requested to use the above template and prepare an abstract of your presentation. Email the abstract to either Dr. Rams or Dr. Govind.
Driving directions and Parking:
Please view the attached pdfs for driving directions to UM, parking garages, and walking directions to the Donna Shalala Student Center on campus.
For places to see in and around Miami:
http://www.miamiandbeaches.com/
https://www.tripadvisor.com/Attractions-g34438-Activities-Miami_Florida.html
PROGRAM
THURSDAY, DEC 20th
8:30 AM - 8:50 AM
Welcome and Introductions
8:50 AM - 9:00 AM
Opening Remarks
SESSION 1
Physiological aspects of amyloids
Chairs: Jennifer Lee & Rams Ramamoorthy
9:00 AM - 10:40 AM
10:40 AM - 11:00 AM
coffee break
SESSION 2
Mechanistic insights into amyloid aggregation
Chairs: Ruth Nussinov & Yanzhuang Wang
11:00 AM - 12:20 PM
12:20 PM - 2:00 PM
Lunch break & poster session
Chairs: Martin Muschol & Jan Münch
Yi Zhu, Xiaojuan Ma, Jinxia Lu, Qian Yang, Yi Xiao, Chong Li, Austin Shin, Jiaqi Liu, Chunyu Jia, Shuai Dou, Houfang Long, Chuchu Wang, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Chao Ma, R. Grace Zhai, Cong Liu, Dan Li
NAD synthase NMNAT chaperones Tau phase separation and pathological aggregation by specific binding to the phosphorylation sites
SESSION 3
Novel techniques to study amyloids
Chairs: Sandrine Ongeri & Alphonso De Simone
2:00 PM - 3:00 PM
SESSION 4
Structural insights into amyloid aggregation
Chairs: Mi Hee Lim & Christian Griesinger
3:00 PM - 4:00 PM
4:00 PM - 4:30 PM
Coffee break
4:30 PM - 5:30 PM
round table discussion
Rakez Kayed
Amyloid antibodies
What are the most promising antibodies?
What are the major drawbacks for medical applications?
What research need to be done to identify the best antibodies?
Christian Griesinger
Amyloid inhibitors vs potential drugs
What makes an amyloid inhibitor suitable to be pipelined to clinics?
What are the challenges in making an amyloid inhibitor to a drug?
Danilo Milardi
Amyloid clearance mechanism
Is it always a good idea to boost amyloid clearance?
What key enabling techniques to be used to address different clearance pathways?
How can we define molecular attributes to fingerprint proteostasis rescuers?
Jan Münch
Amyloids - pro or antimicrobial agents?
Are amyloids more antimicrobial than other antimicrobial peptides?
Are there any connections between antimicrobial and amyloidogenic properties of amyloids?
Claes Wahlestedt
Clinical translation pertaining to amyloid related diseases
What lead to the many disappointing efforts in Alzheimer's disease?
ATTR efforts including oligos.
Tafamidis in FAP and TAC.
6:30 PM
Dinner (By invitation only)
FRIDAY, DEC 21st
SESSION 5
Roles of membrane
Chairs: Sihyun Ham & Varan Govind
9:00 AM - 10:20 AM
Andishesh Abedini
New York University, NY
A new mechanism of IAPP-induced β-cell proteotoxicity in type 2 Diabetes
Dec 21, 9:20 AM
10:20 AM - 10:40 AM
coffee break
SESSION 6
Amyloid aggregation in cells or virus
Chairs: Ursula Jacob & Delia Cabrera DeBuc
10:40 AM - 12:20 PM
12:20 PM - 1:50 PM
Lunch break & poster session
Chairs: Sunil Saxena & Carmelo La Rosa
SESSION 7
Oligomeric intermediaries
Chairs: Lucie Khemtémourian & Katsumi Matsuzaki
1:50 PM - 3:10 PM
Vijay Rangachari
University of Southern Missouri, MO
Connecting the dots: lipid-induced oligomer strains to phenotype in AD
Dec 21, 2:50 PM
3:10 PM - 3:30 PM
coffee break
SESSION 8
Amyloid inhibitors
Chairs: Astrid Gräslund & Rakez Kayed
3:30 PM - 5:10 PM
5:10 PM
Concluding remarks
Varan Govind
HOTELS
2889 McFarlane Road Miami FL 33133
Reservation by phone 305-529-2828 or hotel website (use promo code: UM) for a negotiated rate of USD 149.00 (standard) and USD 169.00 (deluxe) plus state tax (13%) per room, per night. (Dates: December 19-21, 2018)
Distance from University: 4 miles.
Amenities:
Fitness center - 6AM - 10PM
Squash courts - 6AM - 10PM
Panorama restaurant
Panorama sky lounge
Rooftop pool - sunrise to sunset
Business center - 24 Hrs
Concierge services
Room service
Parking: $30.00 per vehicle per day valet parking, in and out privileges
(The Hotel is under new management and will be called Hotel Aria starting December 1st. This will not affect your reservation.)
Sonesta Coconut Grove Miami
3000 Florida Avenue Miami FL 33133
Reservation by phone 305-441-0000 or hotel website for a negotiated rate of USD 179.00 plus state tax (13%) per room, per night. (Dates: December 19-21, 2018). Please book your rooms by November 19 2018 to avail the negotiated rate.
Distance from University: 4 miles.
Amenities:
24-hour fitness center
Spa
Mayfair kitchen restaurant
Rooftop pool
Business center
Free local and 800 access calls
Complimentary WiFi hi speed internet access throughout the hotel.
Mayfair bar
Room service - 6AM -11PM
(More details)
Parking: $30.00 per vehicle per day valet/self parking, in and out privileges
The Mayfair at Coconut Grove
50 SW 12th Street Miami FL 33130
Reservation by phone 786-456-9405 or hotel website for a negotiated rate of USD 169.00 plus state tax (13%) per room, per night. (Dates: December 19-21, 2018)
Distance from University: 7 miles.
About 15 minutes by Metrorail.
Station near the hotel - Brickell
Station near University of Miami - University
Amenities:
Free “Hot Breakfast Buffet” and "On The Run Breakfast Bags"
Free 24-hours coffee, tea, lemonade, hot chocolate & fresh fruits
Free welcome drink at check-in
Welcome letter provided at check-in
Free high-speed wireless internet access in the entire hotel
Free local calls, 800 access calls, and long distance access
Complimentary USA Today newspaper
24-hour business center
24-hour fitness center featuring Precor equipment
Outdoor roof-top pool and whirlpool
Lobby and pool bar with daily happy hour from 5:00pm to 7:00pm located on 6th floor
24-hour convenience store
100% non-smoking environment
Coin laundry room available 7th floor
100% Hampton Satisfaction Guaranteed
Hilton HHonors - Points & Miles Frequent Guest Reward Program
Two restaurants located at hotel: Batch Gastropub and Three Chefs
Parking: $22.00 per vehicle per day- self parking, in and out privileges
Hampton Inn & Suites by Hilton Miami Brickell Downtown
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